La Houille Blanche
Number 4, Août 2003
|Page(s)||31 - 36|
|Published online||01 July 2009|
Microsystème fluidique d'analyse proteomique par ESI-MS
Microfluidic system for proteomics analysis by ESI-MS
USTL, UPRESA CNRS 8009
2 IEMN, UMR CNRS 8520
We report here on the fabrication of a novel silicon microfluidic system dedicated to protein sample preparation prior to their on-line analysis by electrospray and mass spectrometry (ESI-MS). The microsystem includes several main module, such as a digestion cell, an elution column, a pumping system as well as an integrated nano-ESI source, whose realization reflects our technological choice. After a brief presentation on microsystems, we describe our work in microfluidics. the conception and the description of the different modules, the accounting for the retained technological alternatives and the first realizations.
© Société Hydrotechnique de France, 2003
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