La Houille Blanche
Number 5, Octobre-Novembre 2006
|Page(s)||40 - 44|
|Published online||01 June 2007|
Vers une puce microfluidique pour la détection de mutations inconnues et le génotypage
Towards a microfluidic chip for unknown mutation detection and genotyping
Institut Curie, Laboratoire de Physico-Chimie, 11 rue Pierre et Marie Curie, 75005 Paris
Auteur de correspondance : email@example.com
We present some technological tools that should help to adapt a mutation detection method from capillary electrophoresis to « lab on a chip ». The use of chips raises some specific problems, in particular the control of channel coating and the suppression of spurious flow in channels. Our approach was to use adsorbed neutral polymers as a coating in order to avoid electroosmotic flows. We also present here a robust system for flow control in a microchannel system, based on a dynamic control of reservoir pressures at the end of each channel.
Mots clés : Congrès microfluidique 2004
© Société Hydrotechnique de France, 2006
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